There are 40,000 deaths from alcohol abuse per year from a user base of 40,000,000. 500,000 is 1/80th of 40m, so multiply 17 by 80 to get the projected number of deaths if e was as widely used as booze, = 1360. Vs 40,000 for booze.
You can put your head in the sand if you like but those are the numbers, and thats why E is so low on the graph of harm, whereas alcohol is at the top.
I dont consider any deaths acceptable, but the reason for them was poor information on how to take them, which lead to people drinking too much water or overheating. As I already said, there have been zero recorded deaths from poisoning or overdoses. I couldnt find any violence figures but i strongly doubt people take pills and beat up their wives.