I did this recently and my prints turned out EXACTLY like what I see on my screen. I did this at Wal-Mart, don't laugh until you see the results. DON"T deal with CMYK, it blows chunks. Nothing really has the reproduction ability of RGB, I do digital oil paintings, millions of colors.
I had an idea, the other day. I went to Walmart with 5 paintings on a CD. Saved in High resolution 300dpi 8x10 (12 setting in Photoshop) Jpeg. Went to one of those "do it yourself " PHOTOPRINTS. I selected 8 x 10 as I had previously resized my images to those specs.
When they printed out, it blew my f**** doors off. The images came out exactly like I see on my screen. I really was incredibly happy about this. I send my samples to book companys, and all other print attempts failed horribly (CMYK dimension). Personaly I have no interest in selling prints (even though there is dead section attempt on my site). It is quite a feeling to have your digital images so easly reproduced and perfect. Next week I am having 11 x 14s done.
Try it, you'll find it addicting! (4x6 are.38 cents, 8x10 are$5 each)